• In this study we transplant hESC RPE to a large

  2018-11-08

  

  In this study, we transplant hESC-RPE to a large-eyed animal. Human and rabbit eyes are of similar size, the main advantage compared with previously studied mouse and rat models (Carido et al., 2014; Lund et al., 2006). Transplantation in rodents requires high cell concentrations (i.e., typically 50

• Importantly because none of these markers are

  2018-11-08

  

  Importantly, because none of these markers are specific for trophoblast or trophoblast populations in general, they must be used in combination. For example, SWAN-71 and HTR8/SVneo, two widely used “trophoblast” cell lines, are hypermethylated at the ELF5 promoter, HTR8/SVneo does not express C19MC

• Forces generated by actomyosin networks within cells and for

  2018-11-08

  

  Forces generated by actomyosin networks within gnrh antagonist and forces transmitted through intercellular adhesions are coordinated in driving self-organized tissue morphogenesis (Heisenberg and Bellaiche, 2013). We determine that retinal organoid morphogenesis is mediated by ROCK-regulated actom

• The reprogramming of somatic cells was originally demonstrat

  2018-11-08

  

  The reprogramming of somatic endothelin receptor antagonists was originally demonstrated by producing cloned frogs using somatic cell nuclear transfer (SCNT) into Xenopus oocytes (Gurdon et al., 1958). Reprogramming of mammalian somatic cells has also been achieved using SCNT into oocytes, including

• br Data and methodology The study uses

  2018-11-07

  

  Data and methodology The study uses data from the Office for National Statistics (ONS) Longitudinal Study (LS), a 1% extract of 2011 Census records matched to responses from the same individuals at the 2001 and earlier censuses. At the 2001 and 2011 Censuses questions were asked on self-reported

• Sector switchers as those workers who are

  2018-11-07

  

  Sector switchers as those workers who are moving from the private to the public sector or vice versa. Recent studies have indicated that workers switch sectors for many reasons. One reason is related to the occupation’s characteristics (Kaufman and Spilerman, 1982; Su and Bozeman, 2009) and to the w

• br Introducci n En tal sentido la pregunta central

  2018-11-07

  

  Introducción En tal sentido, la pregunta central del trabajo que motivó emprender esta investigación es la siguiente: ¿La globalización es una variable exegética fundamental o existen otros elementos sustantivos para comprender el grado de desarrollo social y económico experimentado en Latinoamér

• En el caso de la pd tiene una tasa de

  2018-11-07

  

  En el caso de la pd, tiene una tasa de participación de 4.6% en 2013, que es más alta que la nacional, aumentando 15.8% en el periodo, ahora bien, si se reconsidera el hecho de que la pnea disponible se debe de contar como desocupadas, entonces, el número de personas en esta condición sería tres vec

• El problema de la deuda El rescate

  2018-11-07

  

  El problema de la deuda El rescate de Grecia por parte de la Troika empezó en mayo de 2010 cuando se le otorga un primer préstamo de aproximadamente 240 mil millones de euros, dado que en octubre de 2009 se descubren las verdaderas cifras del nivel de la deuda pública de Grecia; además de este prés

• br Conclusion The following are the supplementary data

  2018-11-07

  

  Conclusion The following are the supplementary data related to this article. Authors Contributions Declaration of Competing Interests Funding This work was conducted on behalf of the Early Cancer Detection Consortium, within the programme of work for work packages 1 & 2. The Early Cance

• The observation of increases in plasma BPG

  2018-11-07

  

  The observation of increases in plasma 2,3-BPG in the TBI patients, which was unrelated to the patient outcome, is difficult to interpret for two reasons. First, blood concentrations of 2,3-BPG are dominated by the concentration of this metabolite in red blood cells (RBCs), where it acts as an allo

• orthopox br Materials and Methods br Discussion This study i

  2018-11-07

  

  Materials and Methods Discussion This study investigates the effect of treatment on rsFC in neural regions indexing the ‘hot’ emotional, and ‘cold’ cognitive systems in adolescents with MDD. As hypothesized, depressed adolescents had increased rsFC of parts of the ‘hot’ limbic system relative

• A number of clinical proteomics studies have

  2018-11-07

  

  A number of clinical proteomics studies have generated a long list of candidate urine protein biomarkers of various diseases (Beretov et al., 2015; Goodison et al., 2009; Rodriguez-Suarez et al., 2014; Shao, 2015); however, no biomarkers derived from ‘discovery’ studies were successfully translated

• We profiled AR and MYC binding to chromatin and found

  2018-11-07

  

  We profiled AR and MYC binding to chromatin and found that they co-occupy circa one third of the binding sites. We performed RIME and immunoprecipitation experiments in order to comment on how MYC antagonises AR activity but we did not find evidences of direct interaction between the two transcripti

• Our results agree with the strategy of shortening the

  2018-11-07

  

  Our results agree with the strategy of shortening the duration of dual NS5B/NS5A combined therapy to 8weeks, but based on an on-treatment response predictor rather than a baseline variable. This supports the findings of many other studies for the validity of early on-treatment response kinetics as a

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